產(chǎn)品信息 TGF-β家族成員廣泛存在于從果蠅到人多種生物的 各種組織中,對(duì)正常細(xì)胞、癌變細(xì)胞都有著顯著作用。TGF-β除了影響細(xì)胞的增殖、分化,還在胚胎發(fā)育、胞外基質(zhì)形成、 骨的形成和重建等方面起著重要作用 SB 431542: A selective inhibitor of the transforming growth factor-beta (TGF-beta) type I receptor activin receptor-like kinase ALK5 (IC50 = 94 nM), and the related ALK4 and ALK7. 4-(5-BENZOL[1,3]DIOXOL-5-YL-4-PYRLDIN-2-YL-1H-IMIDAZOL-2-YL)-BENZAMIDE Ref: Laping et al. Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor kinase activity: SB-431542. Mol.Pharmacol. 62 58, 2002. Inman et al. SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7. Mol.Pharmacol. 62 65, 2002 Purity: Greater than 98% as determined by LC/MS analysis. LC/MS and/or NMR data available upon request. Biological Activity: Not determined. 重慶市華雅干細(xì)胞技術(shù)有限公司 |